Assay Detail
Functional
CHEMBL4266922
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of S1PR1 (unknown origin) expressed in CHOK1 cells after 90 mins by beta-arresting recuitment assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.38 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4280697 | — | — | 1 | 8.60 |
| CHEMBL1096146 | PONESIMOD | 4.0 | 1 | 7.90 |
| CHEMBL4287514 | — | — | 1 | 7.00 |
| CHEMBL4292022 | — | — | 1 | 6.90 |
| CHEMBL4288608 | — | — | 1 | 6.50 |
| CHEMBL4284144 | — | — | 1 | - |
| CHEMBL4285254 | — | — | 1 | - |
| CHEMBL4292445 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4280697 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL1096146 | PONESIMOD | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL4287514 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4292022 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL4288608 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4284144 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4285254 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4292445 | — | IC50 | > | 1000.0 | nM | - |