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Assay Detail

CHEMBL4266983

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Helicobacter pylori urease after 50 mins by indophenol method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Helicobacter pylori
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Urease (CHEMBL5325)
Type SINGLE PROTEIN
Organism Helicobacter pylori

Publication

Developing potential Helicobacter pylori urease inhibitors from novel oxoindoline derivatives: Synthesis, biological evaluation and in silico study.
Yang YS, Su MM, Zhang XP, Liu QX, He ZX, Xu C, Zhu HL.
Bioorg Med Chem Lett (2018) 28 : 3182 -3186
PubMed 30170940 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 4.88 6.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4293995 1 6.15
CHEMBL4286094 1 5.87
CHEMBL4277785 1 5.42
CHEMBL4278846 1 5.36
CHEMBL4287490 1 5.16
CHEMBL4282631 1 5.09
CHEMBL4289523 1 4.93
CHEMBL4279579 1 4.83
CHEMBL734 ACETOHYDROXAMIC ACID 4.0 1 4.76
CHEMBL4290913 1 4.71
CHEMBL4294307 1 4.64
CHEMBL4289842 1 4.56
CHEMBL4289384 1 4.52
CHEMBL4279161 1 4.42
CHEMBL4283043 1 4.36
CHEMBL4293217 1 4.18
CHEMBL4281503 1 4.08
CHEMBL4291305 1 -
CHEMBL4294712 1 -
CHEMBL4285715 1 -
CHEMBL4286810 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4293995 IC50 = 710.0 nM 6.15
CHEMBL4286094 IC50 = 1350.0 nM 5.87
CHEMBL4277785 IC50 = 3820.0 nM 5.42
CHEMBL4278846 IC50 = 4380.0 nM 5.36
CHEMBL4287490 IC50 = 6990.0 nM 5.16
CHEMBL4282631 IC50 = 8210.0 nM 5.09
CHEMBL4289523 IC50 = 11700.0 nM 4.93
CHEMBL4279579 IC50 = 14900.0 nM 4.83
CHEMBL734 ACETOHYDROXAMIC ACID IC50 = 17200.0 nM 4.76
CHEMBL4290913 IC50 = 19500.0 nM 4.71
CHEMBL4294307 IC50 = 22700.0 nM 4.64
CHEMBL4289842 IC50 = 27600.0 nM 4.56
CHEMBL4289384 IC50 = 29900.0 nM 4.52
CHEMBL4279161 IC50 = 38100.0 nM 4.42
CHEMBL4283043 IC50 = 44100.0 nM 4.36
CHEMBL4293217 IC50 = 65800.0 nM 4.18
CHEMBL4281503 IC50 = 83900.0 nM 4.08
CHEMBL4291305 IC50 = 129000.0 nM -
CHEMBL4294712 IC50 = 143000.0 nM -
CHEMBL4285715 IC50 > 300000.0 nM -
CHEMBL4286810 IC50 = 154000.0 nM -