Assay Detail
Binding
CHEMBL4267189
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Inhibition of Smo-mediated hedgehog signaling pathway in mouse C3H10T1/2 cells after 6 days by Gli-dependent luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Current trends in Hedgehog signaling pathway inhibition by small molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.52 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4287905 | — | — | 1 | 8.55 |
| CHEMBL2031290 | — | — | 1 | 7.82 |
| CHEMBL2031084 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4287905 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2031290 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2031084 | — | IC50 | = | 650.0 | nM | 6.19 |