Assay Detail
Binding
CHEMBL4267485
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human uPA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.70 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4291446 | — | — | 1 | 7.64 |
| CHEMBL4288828 | — | — | 1 | 7.47 |
| CHEMBL4281179 | — | — | 1 | 7.29 |
| CHEMBL4285028 | — | — | 1 | 7.10 |
| CHEMBL4281574 | — | — | 1 | 7.08 |
| CHEMBL4277939 | — | — | 1 | 6.62 |
| CHEMBL4277252 | — | — | 1 | 6.44 |
| CHEMBL4278454 | — | — | 1 | 5.48 |
| CHEMBL4290603 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4291446 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4288828 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4281179 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4285028 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4281574 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4277939 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL4277252 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4278454 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL4290603 | — | IC50 | = | 7260.0 | nM | 5.14 |