Assay Detail
Binding
CHEMBL4267486
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Inhibition of human tPA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.79 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4281179 | — | — | 1 | 6.33 |
| CHEMBL4281574 | — | — | 1 | 5.84 |
| CHEMBL4277939 | — | — | 1 | 5.80 |
| CHEMBL4285028 | — | — | 1 | 5.80 |
| CHEMBL4291446 | — | — | 1 | 5.73 |
| CHEMBL4288828 | — | — | 1 | 5.24 |
| CHEMBL4278454 | — | — | 1 | - |
| CHEMBL4277252 | — | — | 1 | - |
| CHEMBL4290603 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4281179 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4281574 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL4277939 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4285028 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL4291446 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL4288828 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4278454 | — | IC50 | - | — | - | |
| CHEMBL4277252 | — | IC50 | - | — | - | |
| CHEMBL4290603 | — | IC50 | > | 30000.0 | nM | - |