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Assay Detail

CHEMBL4267872

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]2-chloro-N 6- methyl-( N )-methanocarba-2'-deoxyadenosine 3 ' ,5 '-bis-phosphate from human P2Y1 expressed in baculovirus infected insect Sf9 cells after 30 mins by scintillation spectrometric method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Sf9
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

P2Y purinoceptor 1 (CHEMBL4315)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y1 receptor antagonists.
Peng J, Zhao L, Wang L, Chen H, Qiu Y, Wang J, Yang H, Liu J, Liu H.
Eur J Med Chem (2018) 158 : 302 -310
PubMed 30223118 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.11 9.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL444278 1 9.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL444278 Ki = 0.78 nM 9.11