Assay Detail
Binding
CHEMBL4267922
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Inhibition of HIV1 reverse transcriptase K103N mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.19 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70517 | — | — | 1 | 9.40 |
| CHEMBL312764 | — | — | 1 | 9.05 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.92 |
| CHEMBL72528 | — | — | 1 | 8.89 |
| CHEMBL308004 | — | — | 1 | 8.77 |
| CHEMBL70442 | — | — | 1 | 8.72 |
| CHEMBL69890 | — | — | 1 | 8.59 |
| CHEMBL72335 | — | — | 1 | 8.57 |
| CHEMBL72242 | — | — | 1 | 8.48 |
| CHEMBL307950 | — | — | 1 | 8.24 |
| CHEMBL71881 | — | — | 1 | 8.21 |
| CHEMBL70514 | — | — | 1 | 8.00 |
| CHEMBL74239 | — | — | 1 | 7.92 |
| CHEMBL72652 | — | — | 1 | 7.41 |
| CHEMBL307297 | — | — | 1 | 7.40 |
| CHEMBL421112 | — | — | 1 | 4.48 |
| CHEMBL302360 | — | — | 1 | - |
| CHEMBL74226 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70517 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL312764 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL308954 | ETRAVIRINE | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL72528 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL308004 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL70442 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL69890 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL72335 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL72242 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL307950 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL71881 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL70514 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL74239 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL72652 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL307297 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL421112 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL302360 | — | IC50 | - | — | - | |
| CHEMBL74226 | — | IC50 | > | 100000.0 | nM | - |