Assay Detail
Binding
CHEMBL4267983
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Inhibition of PI3KCgamma (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Piperidinyl-embeded chalcones possessing anti PI3Kδ inhibitory properties exhibit anti-atopic properties in preclinical models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.51 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3039502 | DUVELISIB | 4.0 | 1 | 7.92 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 6.60 |
| CHEMBL4287949 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3039502 | DUVELISIB | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4287949 | — | IC50 | = | 10000.0 | nM | 5.00 |