Assay Detail
Binding
CHEMBL4268301
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PDE7A using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (CHEMBL3012) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.70 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484928 | — | — | 1 | 5.68 |
| CHEMBL4289050 | — | — | 1 | 5.29 |
| CHEMBL4284497 | — | — | 1 | 5.11 |
| CHEMBL4282582 | — | — | 1 | 5.04 |
| CHEMBL4280337 | — | — | 1 | 4.70 |
| CHEMBL4292772 | — | — | 1 | 4.70 |
| CHEMBL4291934 | — | — | 1 | 4.42 |
| CHEMBL4290956 | — | — | 1 | 4.39 |
| CHEMBL4290996 | — | — | 1 | 4.26 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | — | 1 | 4.07 |
| CHEMBL4288977 | — | — | 1 | 4.02 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
| CHEMBL4280678 | — | — | 1 | - |
| CHEMBL4290575 | — | — | 1 | - |
| CHEMBL4294138 | — | — | 1 | - |
| CHEMBL4287148 | — | — | 1 | - |
| CHEMBL4279233 | — | — | 1 | - |
| CHEMBL4283794 | — | — | 1 | - |
| CHEMBL4294370 | — | — | 1 | - |
| CHEMBL4284046 | — | — | 1 | - |
| CHEMBL4290979 | — | — | 1 | - |
| CHEMBL4290814 | — | — | 1 | - |
| CHEMBL4280173 | — | — | 1 | - |
| CHEMBL4287403 | — | — | 1 | - |
| CHEMBL4276743 | — | — | 1 | - |
| CHEMBL1086310 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484928 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4289050 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL4284497 | — | IC50 | = | 7760.0 | nM | 5.11 |
| CHEMBL4282582 | — | IC50 | = | 9060.0 | nM | 5.04 |
| CHEMBL4280337 | — | IC50 | = | 19750.0 | nM | 4.70 |
| CHEMBL4292772 | — | IC50 | = | 19960.0 | nM | 4.70 |
| CHEMBL4291934 | — | IC50 | = | 37590.0 | nM | 4.42 |
| CHEMBL4290956 | — | IC50 | = | 41150.0 | nM | 4.39 |
| CHEMBL4290996 | — | IC50 | = | 54280.0 | nM | 4.26 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | IC50 | = | 85600.0 | nM | 4.07 |
| CHEMBL4288977 | — | IC50 | = | 96320.0 | nM | 4.02 |
| CHEMBL63 | ROLIPRAM | IC50 | > | 200000.0 | nM | - |
| CHEMBL4280678 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4290575 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4294138 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4287148 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4279233 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4283794 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4294370 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4284046 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4290979 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4290814 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4280173 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4287403 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4276743 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1086310 | — | IC50 | > | 200000.0 | nM | - |