Assay Detail
ADMET
CHEMBL4268534
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Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using ZMAL as substrate measured after 90 mins by fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.38 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4162282 | — | — | 1 | 7.52 |
| CHEMBL4280840 | — | — | 1 | 7.51 |
| CHEMBL4283545 | — | — | 1 | 7.50 |
| CHEMBL4278449 | — | — | 1 | 7.46 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.26 |
| CHEMBL4289151 | — | — | 1 | 7.24 |
| CHEMBL4292530 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4162282 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4280840 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4283545 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4278449 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4289151 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4292530 | — | IC50 | = | 64.0 | nM | 7.19 |