Assay Detail
Functional
CHEMBL4268562
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Antiproliferative activity against human SNU5 cells after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Exploration of novel pyrrolo[2,1-f][1,2,4]triazine derivatives with improved anticancer efficacy as dual inhibitors of c-Met/VEGFR-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.83 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | 8.05 |
| CHEMBL4282387 | — | — | 1 | 7.94 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 7.92 |
| CHEMBL2103868 | CABOZANTINIB S-MALATE | 4.0 | 1 | 7.88 |
| CHEMBL4285034 | — | — | 1 | 7.85 |
| CHEMBL4292983 | — | — | 1 | 7.80 |
| CHEMBL4292884 | — | — | 1 | 7.79 |
| CHEMBL4277848 | — | — | 1 | 7.78 |
| CHEMBL4276790 | — | — | 1 | 7.74 |
| CHEMBL4287439 | — | — | 1 | 7.72 |
| CHEMBL4285792 | — | — | 1 | 7.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL4282387 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL2103868 | CABOZANTINIB S-MALATE | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL4285034 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL4292983 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL4292884 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL4277848 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL4276790 | — | IC50 | = | 18.4 | nM | 7.74 |
| CHEMBL4287439 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL4285792 | — | IC50 | = | 24.6 | nM | 7.61 |