Assay Detail
Functional
CHEMBL4268703
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Antiproliferative activity against human SJSA1 cells by Edu incorporation assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SJSA-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The development of piperidinones as potent MDM2-P53 protein-protein interaction inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.81 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3125527 | — | — | 1 | 8.52 |
| CHEMBL3125517 | — | — | 1 | 8.30 |
| CHEMBL3125710 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3125527 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3125517 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3125710 | — | IC50 | = | 240.0 | nM | 6.62 |