Assay Detail
Functional
CHEMBL4268714
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Cytotoxicity against imatinib-sensitive human K562 cells assessed as decrease in cell viability after 24 hrs by XTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.52 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL941 | IMATINIB | 4.0 | 1 | 6.00 |
| CHEMBL4279418 | — | — | 1 | 5.19 |
| CHEMBL4294145 | — | — | 1 | 5.00 |
| CHEMBL4289670 | — | — | 1 | 4.92 |
| CHEMBL4286253 | — | — | 1 | 4.60 |
| CHEMBL4282448 | — | — | 1 | 4.53 |
| CHEMBL4278991 | — | — | 1 | 4.49 |
| CHEMBL4293078 | — | — | 1 | 4.32 |
| CHEMBL4277944 | — | — | 1 | 4.30 |
| CHEMBL4278359 | — | — | 1 | 4.24 |
| CHEMBL4290101 | — | — | 1 | 4.23 |
| CHEMBL4289687 | — | — | 1 | 4.23 |
| CHEMBL4281817 | — | — | 1 | 4.18 |
| CHEMBL4286268 | — | — | 1 | 4.18 |
| CHEMBL482686 | — | — | 1 | 4.17 |
| CHEMBL2414454 | — | — | 1 | 4.16 |
| CHEMBL4288599 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL941 | IMATINIB | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4279418 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4294145 | — | IC50 | = | 10110.0 | nM | 5.00 |
| CHEMBL4289670 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4286253 | — | IC50 | = | 25020.0 | nM | 4.60 |
| CHEMBL4282448 | — | IC50 | = | 29510.0 | nM | 4.53 |
| CHEMBL4278991 | — | IC50 | = | 32470.0 | nM | 4.49 |
| CHEMBL4293078 | — | IC50 | = | 47500.0 | nM | 4.32 |
| CHEMBL4277944 | — | IC50 | = | 49890.0 | nM | 4.30 |
| CHEMBL4278359 | — | IC50 | = | 57410.0 | nM | 4.24 |
| CHEMBL4290101 | — | IC50 | = | 58870.0 | nM | 4.23 |
| CHEMBL4289687 | — | IC50 | = | 59480.0 | nM | 4.23 |
| CHEMBL4281817 | — | IC50 | = | 66090.0 | nM | 4.18 |
| CHEMBL4286268 | — | IC50 | = | 66500.0 | nM | 4.18 |
| CHEMBL482686 | — | IC50 | = | 68300.0 | nM | 4.17 |
| CHEMBL2414454 | — | IC50 | = | 69090.0 | nM | 4.16 |
| CHEMBL4288599 | — | IC50 | = | 74570.0 | nM | 4.13 |