Assay Detail
Binding
CHEMBL4268780
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Inhibition of human DAO using D-serine as substrate after 20 mins in presence of FAD
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural basis for potent inhibition of d-amino acid oxidase by thiophene carboxylic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.56 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4287507 | — | — | 1 | 7.44 |
| CHEMBL4285389 | — | — | 1 | 7.05 |
| CHEMBL4276865 | — | — | 1 | 6.66 |
| CHEMBL4292441 | — | — | 1 | 6.44 |
| CHEMBL4280438 | — | — | 1 | 6.14 |
| CHEMBL4291755 | — | — | 1 | 5.89 |
| CHEMBL4293210 | — | — | 1 | 5.89 |
| CHEMBL4290664 | — | — | 1 | 5.89 |
| CHEMBL4288339 | — | — | 1 | 5.85 |
| CHEMBL164585 | — | — | 1 | 5.36 |
| CHEMBL4283897 | — | — | 1 | 5.34 |
| CHEMBL1452423 | — | — | 1 | 5.14 |
| CHEMBL1222314 | THIOPHENE CARBOXYLIC ACID | — | 1 | 5.11 |
| CHEMBL4295194 | — | — | 1 | 5.06 |
| CHEMBL4287252 | — | — | 1 | 4.68 |
| CHEMBL4288645 | — | — | 1 | 4.57 |
| CHEMBL4292062 | — | — | 1 | 4.42 |
| CHEMBL4284181 | — | — | 1 | 4.41 |
| CHEMBL4287566 | — | — | 1 | 4.26 |
| CHEMBL4277294 | — | — | 1 | - |
| CHEMBL4285249 | — | — | 1 | - |
| CHEMBL1378288 | — | — | 1 | - |
| CHEMBL4293485 | — | — | 1 | - |
| CHEMBL4280023 | — | — | 1 | - |
| CHEMBL142592 | — | — | 1 | - |
| CHEMBL4280745 | — | — | 1 | - |
| CHEMBL4285304 | — | — | 1 | - |
| CHEMBL4277348 | — | — | 1 | - |
| CHEMBL4276924 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4287507 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4285389 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4276865 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4292441 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4280438 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4291755 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4293210 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4290664 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4288339 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL164585 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4283897 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1452423 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL1222314 | THIOPHENE CARBOXYLIC ACID | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4295194 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4287252 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4288645 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4292062 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL4284181 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL4287566 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL4277294 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4285249 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1378288 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4293485 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4280023 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL142592 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4280745 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4285304 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4277348 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4276924 | — | IC50 | > | 100000.0 | nM | - |