Assay Detail
Functional
CHEMBL4268985
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Cytotoxicity against human 8505C cells after 96 hrs by sulforhodamine B assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 8505C |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Transformation of asiatic acid into a mitocanic, bimodal-acting rhodamine B conjugate of nanomolar cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.25 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4277168 | — | — | 1 | 6.50 |
| CHEMBL4280590 | — | — | 1 | 5.82 |
| CHEMBL3785137 | — | — | 1 | 4.93 |
| CHEMBL404313 | ASIATIC ACID | — | 1 | 4.78 |
| CHEMBL201515 | MASLINIC ACID | — | 1 | 4.77 |
| CHEMBL4291236 | — | — | 1 | 4.70 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | - |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | - |
| CHEMBL4281011 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4277168 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4280590 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3785137 | — | EC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL404313 | ASIATIC ACID | EC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL201515 | MASLINIC ACID | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4291236 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL168 | OLEANOLIC_ACID | EC50 | > | 30000.0 | nM | - |
| CHEMBL269277 | BETULINIC ACID | EC50 | - | — | - | |
| CHEMBL4281011 | — | EC50 | - | — | - |