Assay Detail
Functional
CHEMBL4269044
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Antiviral activity against Hepatitis B virus infected in human dHepaRG cells assessed as reduction in extracellular viral DNA levels after 6 days by qPCR/TaqMan assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.36 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314362 | ENTECAVIR | 4.0 | 1 | 10.22 |
| CHEMBL4283853 | — | — | 1 | 8.49 |
| CHEMBL4294968 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314362 | ENTECAVIR | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL4283853 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4294968 | — | IC50 | > | 1000.0 | nM | - |