Assay Detail
Binding
CHEMBL4269217
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full-length His6-tagged human P300 expressed in Baculovirus-infected Sf21 cells using histone as substrate after 10 mins in presence of [3H]-acetyl-CoA by autoradiographic analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.16 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445599 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445599 | — | IC50 | = | 7000.0 | nM | 5.16 |