Assay Detail
Binding
CHEMBL4269386
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BuChE in Swiss Webster mouse whole blood serum using butyrylthiocholine iodide as substrate preincubated for 10 mins followed substrate addition measured after 10 mins by Ellman's method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.62 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4280262 | — | — | 1 | 8.31 |
| CHEMBL32823 | — | — | 1 | 8.04 |
| CHEMBL4279148 | — | — | 1 | 7.93 |
| CHEMBL4283717 | — | — | 1 | 7.59 |
| CHEMBL4282214 | — | — | 1 | 7.58 |
| CHEMBL4287068 | — | — | 1 | 7.56 |
| CHEMBL4294287 | — | — | 1 | 7.51 |
| CHEMBL4290902 | — | — | 1 | 7.43 |
| CHEMBL4287482 | — | — | 1 | 7.43 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.20 |
| CHEMBL4276832 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4280262 | — | IC50 | = | 4.93 | nM | 8.31 |
| CHEMBL32823 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL4279148 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL4283717 | — | IC50 | = | 25.8 | nM | 7.59 |
| CHEMBL4282214 | — | IC50 | = | 26.2 | nM | 7.58 |
| CHEMBL4287068 | — | IC50 | = | 27.6 | nM | 7.56 |
| CHEMBL4294287 | — | IC50 | = | 30.8 | nM | 7.51 |
| CHEMBL4290902 | — | IC50 | = | 36.9 | nM | 7.43 |
| CHEMBL4287482 | — | IC50 | = | 36.7 | nM | 7.43 |
| CHEMBL95 | TACRINE | IC50 | = | 62.5 | nM | 7.20 |
| CHEMBL4276832 | — | IC50 | = | 64.3 | nM | 7.19 |