Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4269443

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes measured after 72 hrs by malstat reagent based LDH release assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme.
Sakata Y, Yabunaka K, Kobayashi Y, Omiya H, Umezawa N, Kim HS, Wataya Y, Tomita Y, Hisamatsu Y, Kato N, Yagi H, Satoh T, Kato K, Ishikawa H, Higuchi T.
ACS Med Chem Lett (2018) 9 : 980 -985
PubMed 30344903 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.41 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4281618 1 8.00
CHEMBL138071 1 7.68
CHEMBL4292248 1 7.55
CHEMBL4291844 1 7.43
CHEMBL46524 1 7.36
CHEMBL4282488 1 7.35
CHEMBL4283980 1 6.57
CHEMBL4280541 1 6.43
CHEMBL76 CHLOROQUINE 4.0 1 6.24
CHEMBL4288424 1 6.12
CHEMBL4293986 1 6.06
CHEMBL4290757 1 5.96
CHEMBL4290344 1 5.51
CHEMBL4287339 1 4.75
CHEMBL4282472 1 4.75
CHEMBL4280118 1 4.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4281618 IC50 = 10.0 nM 8.00
CHEMBL138071 IC50 = 21.0 nM 7.68
CHEMBL4292248 IC50 = 28.0 nM 7.55
CHEMBL4291844 IC50 = 37.0 nM 7.43
CHEMBL46524 IC50 = 44.0 nM 7.36
CHEMBL4282488 IC50 = 45.0 nM 7.35
CHEMBL4283980 IC50 = 270.0 nM 6.57
CHEMBL4280541 IC50 = 370.0 nM 6.43
CHEMBL76 CHLOROQUINE IC50 = 570.0 nM 6.24
CHEMBL4288424 IC50 = 750.0 nM 6.12
CHEMBL4293986 IC50 = 870.0 nM 6.06
CHEMBL4290757 IC50 = 1100.0 nM 5.96
CHEMBL4290344 IC50 = 3100.0 nM 5.51
CHEMBL4287339 IC50 = 18000.0 nM 4.75
CHEMBL4282472 IC50 = 18000.0 nM 4.75
CHEMBL4280118 IC50 = 19000.0 nM 4.72