Assay Detail
Functional
CHEMBL4269484
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania major intracellular amastigotes harboring luciferase infected in mouse RAW264.7 cells after 96 hrs by luminescence assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania major |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 36 | 5.40 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.46 |
| CHEMBL4287195 | — | — | 1 | 6.42 |
| CHEMBL4283366 | — | — | 1 | 5.85 |
| CHEMBL4279269 | — | — | 1 | 5.80 |
| CHEMBL4287808 | — | — | 1 | 5.60 |
| CHEMBL4293105 | — | — | 1 | 5.40 |
| CHEMBL4284550 | — | — | 1 | 5.39 |
| CHEMBL495979 | — | — | 1 | 5.38 |
| CHEMBL4292440 | — | — | 1 | 5.37 |
| CHEMBL4288115 | — | — | 1 | 5.34 |
| CHEMBL4277293 | — | — | 1 | 5.27 |
| CHEMBL4281306 | — | — | 1 | 5.26 |
| CHEMBL4279896 | — | — | 1 | 5.26 |
| CHEMBL4287935 | — | — | 1 | 5.23 |
| CHEMBL4291210 | — | — | 1 | 5.22 |
| CHEMBL4291924 | — | — | 1 | 5.19 |
| CHEMBL4280687 | — | — | 1 | 5.16 |
| CHEMBL4289030 | — | — | 1 | 5.14 |
| CHEMBL4284713 | — | — | 1 | 5.12 |
| CHEMBL4291524 | — | — | 1 | 5.09 |
| CHEMBL4290423 | — | — | 1 | 5.05 |
| CHEMBL4285290 | — | — | 1 | 5.04 |
| CHEMBL4281134 | — | — | 1 | 5.03 |
| CHEMBL4280205 | — | — | 1 | 5.00 |
| CHEMBL4290139 | — | — | 1 | 4.96 |
| CHEMBL4280380 | — | — | 1 | - |
| CHEMBL4283656 | — | — | 1 | - |
| CHEMBL4294413 | — | — | 1 | - |
| CHEMBL4283836 | — | — | 1 | - |
| CHEMBL4293909 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4287195 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4283366 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4279269 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4287808 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4293105 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4284550 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL495979 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4292440 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4288115 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4277293 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4281306 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4279896 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4287935 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4291210 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4291924 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4280687 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4289030 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4284713 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4291524 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4290423 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4285290 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4281134 | — | EC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4280205 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4290139 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4294610 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4279460 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4279771 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4291341 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4286712 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4286008 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4293909 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4283836 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4294413 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL4283656 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4280380 | — | EC50 | > | 2000.0 | nM | - |