Assay Detail
Functional
CHEMBL4269486
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Antimalarial activity against Plasmodium falciparum D6 trophozoites after 72 hrs by SYBR Green I dye-based fluorescence assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 36 | 5.90 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.05 |
| CHEMBL4292440 | — | — | 1 | 6.85 |
| CHEMBL4280205 | — | — | 1 | 6.80 |
| CHEMBL4291524 | — | — | 1 | 6.58 |
| CHEMBL4285290 | — | — | 1 | 6.42 |
| CHEMBL4283656 | — | — | 1 | 6.19 |
| CHEMBL4283366 | — | — | 1 | 6.10 |
| CHEMBL495979 | — | — | 1 | 6.03 |
| CHEMBL4283836 | — | — | 1 | 5.96 |
| CHEMBL4277293 | — | — | 1 | 5.96 |
| CHEMBL4284550 | — | — | 1 | 5.89 |
| CHEMBL4280687 | — | — | 1 | 5.82 |
| CHEMBL4279896 | — | — | 1 | 5.82 |
| CHEMBL4279269 | — | — | 1 | 5.77 |
| CHEMBL4293105 | — | — | 1 | 5.72 |
| CHEMBL4287195 | — | — | 1 | 5.70 |
| CHEMBL4289030 | — | — | 1 | 5.52 |
| CHEMBL4291924 | — | — | 1 | 5.52 |
| CHEMBL4284713 | — | — | 1 | 5.52 |
| CHEMBL4291341 | — | — | 1 | 5.44 |
| CHEMBL4288115 | — | — | 1 | 5.42 |
| CHEMBL4290139 | — | — | 1 | 5.32 |
| CHEMBL4293909 | — | — | 1 | 5.24 |
| CHEMBL4286712 | — | — | 1 | 5.24 |
| CHEMBL4281134 | — | — | 1 | 5.23 |
| CHEMBL4281306 | — | — | 1 | 5.23 |
| CHEMBL4287935 | — | — | 1 | - |
| CHEMBL4280380 | — | — | 1 | - |
| CHEMBL4294610 | — | — | 1 | - |
| CHEMBL4286008 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | EC50 | = | 8.9 | nM | 8.05 |
| CHEMBL4292440 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4280205 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4291524 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4285290 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4283656 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4283366 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL495979 | — | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL4283836 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4277293 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4284550 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4280687 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4279896 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4279269 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4293105 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4287195 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4284713 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4289030 | — | EC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL4291924 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4291341 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4288115 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4290139 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4293909 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4286712 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4281134 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4281306 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4287808 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4290423 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4279771 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4279460 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4294413 | — | EC50 | > | 3600.0 | nM | - |
| CHEMBL4291210 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4286008 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4294610 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4280380 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4287935 | — | EC50 | > | 15000.0 | nM | - |