Assay Detail
Binding
CHEMBL4269699
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Inhibition of mTOR (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.08 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4281240 | — | — | 1 | 7.47 |
| CHEMBL2325697 | — | — | 1 | 7.42 |
| CHEMBL4291436 | — | — | 1 | 7.28 |
| CHEMBL3648329 | — | — | 1 | 6.82 |
| CHEMBL4285417 | CERALASERTIB | 3.0 | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4281240 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2325697 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4291436 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3648329 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4285417 | CERALASERTIB | IC50 | = | 370.0 | nM | 6.43 |