Assay Detail
Binding
CHEMBL4269804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human intestinal carboxylesterase using o-nitrophenyl acetate as substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza ("Danshen").
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.07 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285759 | — | — | 1 | 9.21 |
| CHEMBL4293626 | — | — | 1 | 9.12 |
| CHEMBL4282357 | — | — | 1 | 9.09 |
| CHEMBL4290236 | — | — | 1 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285759 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL4293626 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL4282357 | — | Ki | = | 0.82 | nM | 9.09 |
| CHEMBL4290236 | — | Ki | = | 1.4 | nM | 8.85 |