Assay Detail
Binding
CHEMBL4270048
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Binding affinity to KDM5A ARID/PhD1 domain deletion mutant (1 to 588 residues) (unknown origin) by ITC assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 5.72 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081571 | — | — | 1 | 6.82 |
| CHEMBL4284220 | — | — | 1 | 6.58 |
| CHEMBL4283844 | — | — | 1 | 5.22 |
| CHEMBL4294426 | — | — | 1 | 5.05 |
| CHEMBL3188597 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081571 | — | Kd | = | 150.0 | nM | 6.82 |
| CHEMBL4284220 | — | Kd | = | 260.0 | nM | 6.58 |
| CHEMBL4283844 | — | Kd | = | 6000.0 | nM | 5.22 |
| CHEMBL4294426 | — | Kd | = | 9000.0 | nM | 5.05 |
| CHEMBL3188597 | — | Kd | = | 12000.0 | nM | 4.92 |