Assay Detail
Binding
CHEMBL4270233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human p97 in human HeLa cells harboring UbG76V-GFP assessed as accumulation of UbG76V after 1 hr by microscopic analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transitional endoplasmic reticulum ATPase (CHEMBL1075145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.13 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2311578 | — | — | 1 | 5.85 |
| CHEMBL4280801 | — | — | 1 | 4.82 |
| CHEMBL4288865 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2311578 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4280801 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4288865 | — | EC50 | = | 19000.0 | nM | 4.72 |