Assay Detail
Functional
CHEMBL4270677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human K562 cells assessed as decrease in cell proliferation after 72 hrs by calcein AM staining-based assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
ALK5 kinase inhibitory activity and synthesis of 2,3,4-substituted 5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 4.23 | 4.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4279172 | — | — | 1 | 4.62 |
| CHEMBL4291675 | — | — | 1 | 4.51 |
| CHEMBL4294411 | — | — | 1 | 4.35 |
| CHEMBL4292491 | — | — | 1 | 4.28 |
| CHEMBL4284266 | — | — | 1 | 4.19 |
| CHEMBL4281195 | — | — | 1 | 4.13 |
| CHEMBL4287261 | — | — | 1 | 4.11 |
| CHEMBL4283308 | — | — | 1 | 4.11 |
| CHEMBL4287412 | — | — | 1 | 4.09 |
| CHEMBL4292170 | — | — | 1 | 4.06 |
| CHEMBL4289487 | — | — | 1 | 4.04 |
| CHEMBL4284434 | — | — | 1 | - |
| CHEMBL4281030 | — | — | 1 | - |
| CHEMBL4277021 | — | — | 1 | - |
| CHEMBL4287654 | — | — | 1 | - |
| CHEMBL4285400 | — | — | 1 | - |
| CHEMBL4277446 | — | — | 1 | - |
| CHEMBL4288745 | — | — | 1 | - |
| CHEMBL4279331 | — | — | 1 | - |
| CHEMBL4278812 | — | — | 1 | - |
| CHEMBL4292878 | — | — | 1 | - |
| CHEMBL4279935 | — | — | 1 | - |
| CHEMBL185238 | GW786460X | — | 1 | - |
| CHEMBL4291439 | — | — | 1 | - |
| CHEMBL4284609 | — | — | 1 | - |
| CHEMBL4276896 | — | — | 1 | - |
| CHEMBL4285692 | — | — | 1 | - |
| CHEMBL4277755 | — | — | 1 | - |
| CHEMBL2364611 | GALUNISERTIB | 2.0 | 1 | - |
| CHEMBL4282287 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4279172 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4291675 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4294411 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL4292491 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL4284266 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL4281195 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL4287261 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL4283308 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL4287412 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL4292170 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL4289487 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL4287843 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4284434 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4281030 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4277021 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4287654 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4285400 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4277446 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4288745 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4279331 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL4278812 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL4292878 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4279935 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL185238 | GW786460X | IC50 | > | 100000.0 | nM | - |
| CHEMBL4291439 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4284609 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4276896 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4285692 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4277755 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2364611 | GALUNISERTIB | IC50 | - | — | - | |
| CHEMBL4282287 | — | IC50 | > | 100000.0 | nM | - |