Assay Detail
Binding
CHEMBL4271323
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK4 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural insights of cyclin dependent kinases: Implications in design of selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.09 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545110 | RIBOCICLIB | 4.0 | 1 | 8.70 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 8.70 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 7.96 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545110 | RIBOCICLIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 100.0 | nM | 7.00 |