Assay Detail

CHEMBL4271419

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Binding

Inhibition of PI3K p110gamma/p85alpha (unknown origin) assessed as reduction in PIP2 to PIP3 conversion by HTRF assay

ChEMBL ↗

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Target

PIK3CG/PIK3R1 (CHEMBL4296106) ↗

Open DB target context

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PIK3CG/PIK3R1 (CHEMBL4296106) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target PIK3CG/PIK3R1

CHEMBL4296106

Anchored from Assay target.

Protein identity PIK3CG/PIK3R1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	7 — Homologous single protein target
Curated By	Intermediate

Target

PIK3CG/PIK3R1 (CHEMBL4296106) ↗

Type	PROTEIN COMPLEX
Organism	Homo sapiens

Publication

1,3,5-Triazines: A promising scaffold for anticancer drugs development.

Cascioferro S, Parrino B, Spanò V, Carbone A, Montalbano A, Barraja P, Diana P, Cirrincione G.
Eur J Med Chem (2017) 142 : 523 -549
PubMed 29046238 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.34	8.34

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL586702	ZSTK-474	2.0	1	8.34

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL586702	ZSTK-474	IC50	=	4.6	nM	8.34