Assay Detail
Functional
CHEMBL4271565
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Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New pyrazolopyridine analogs: Synthesis, antimicrobial, antiquorum-sensing and antitumor screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.70 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.35 |
| CHEMBL4290578 | — | — | 1 | 5.28 |
| CHEMBL4289503 | — | — | 1 | 5.20 |
| CHEMBL4292895 | — | — | 1 | 5.06 |
| CHEMBL4293981 | — | — | 1 | 4.69 |
| CHEMBL4282699 | — | — | 1 | 4.40 |
| CHEMBL4286075 | — | — | 1 | 4.40 |
| CHEMBL4283801 | — | — | 1 | 4.24 |
| CHEMBL4282300 | — | — | 1 | 4.18 |
| CHEMBL4294374 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4290578 | — | IC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL4289503 | — | IC50 | = | 6320.0 | nM | 5.20 |
| CHEMBL4292895 | — | IC50 | = | 8680.0 | nM | 5.06 |
| CHEMBL4293981 | — | IC50 | = | 20560.0 | nM | 4.69 |
| CHEMBL4282699 | — | IC50 | = | 39660.0 | nM | 4.40 |
| CHEMBL4286075 | — | IC50 | = | 39470.0 | nM | 4.40 |
| CHEMBL4283801 | — | IC50 | = | 57850.0 | nM | 4.24 |
| CHEMBL4282300 | — | IC50 | = | 66410.0 | nM | 4.18 |
| CHEMBL4294374 | — | IC50 | = | 66260.0 | nM | 4.18 |