Assay Detail
Binding
CHEMBL4272250
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal flag-tagged JNK1 (unknown origin) expressed in baculovirus expression system after 60 mins in presence of [gamma-32P]ATP by topcount scintillation method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and biological evaluation of novel triaryl pyrazoline derivatives with dioxane moiety for selective BRAFV600E inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.04 | 4.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4294787 | — | — | 1 | 4.05 |
| CHEMBL4290513 | — | — | 1 | 4.03 |
| CHEMBL4277125 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4294787 | — | IC50 | = | 88900.0 | nM | 4.05 |
| CHEMBL4290513 | — | IC50 | = | 93600.0 | nM | 4.03 |
| CHEMBL4277125 | — | IC50 | > | 200000.0 | nM | - |