Assay Detail
Binding
CHEMBL4273053
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Inhibition of human recombinant carbonic anhydrase 9 assessed as CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye-based stopped-flow assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.17 | 7.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.59 |
| CHEMBL4293582 | — | — | 1 | 7.52 |
| CHEMBL4277666 | — | — | 1 | 7.02 |
| CHEMBL4281925 | — | — | 1 | 6.82 |
| CHEMBL4285604 | — | — | 1 | 6.79 |
| CHEMBL4281197 | — | — | 1 | 6.63 |
| CHEMBL4288695 | — | — | 1 | 6.56 |
| CHEMBL4285726 | — | — | 1 | 5.98 |
| CHEMBL4287995 | — | — | 1 | 5.91 |
| CHEMBL4280099 | — | — | 1 | 5.89 |
| CHEMBL4279656 | — | — | 1 | 5.79 |
| CHEMBL4292534 | — | — | 1 | 5.78 |
| CHEMBL4288399 | — | — | 1 | 5.76 |
| CHEMBL4280796 | — | — | 1 | 5.75 |
| CHEMBL4277397 | — | — | 1 | 5.74 |
| CHEMBL4292113 | — | — | 1 | 5.73 |
| CHEMBL4285351 | — | — | 1 | 5.72 |
| CHEMBL4284225 | — | — | 1 | 5.71 |
| CHEMBL4277762 | — | — | 1 | 5.71 |
| CHEMBL4291819 | — | — | 1 | 5.65 |
| CHEMBL4290322 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.8 | nM | 7.59 |
| CHEMBL4293582 | — | Ki | = | 30.4 | nM | 7.52 |
| CHEMBL4277666 | — | Ki | = | 95.2 | nM | 7.02 |
| CHEMBL4281925 | — | Ki | = | 151.5 | nM | 6.82 |
| CHEMBL4285604 | — | Ki | = | 162.7 | nM | 6.79 |
| CHEMBL4281197 | — | Ki | = | 235.3 | nM | 6.63 |
| CHEMBL4288695 | — | Ki | = | 275.7 | nM | 6.56 |
| CHEMBL4285726 | — | Ki | = | 1046.3 | nM | 5.98 |
| CHEMBL4287995 | — | Ki | = | 1243.6 | nM | 5.91 |
| CHEMBL4280099 | — | Ki | = | 1272.6 | nM | 5.89 |
| CHEMBL4279656 | — | Ki | = | 1631.4 | nM | 5.79 |
| CHEMBL4292534 | — | Ki | = | 1660.9 | nM | 5.78 |
| CHEMBL4288399 | — | Ki | = | 1738.1 | nM | 5.76 |
| CHEMBL4280796 | — | Ki | = | 1788.6 | nM | 5.75 |
| CHEMBL4277397 | — | Ki | = | 1841.0 | nM | 5.74 |
| CHEMBL4292113 | — | Ki | = | 1853.6 | nM | 5.73 |
| CHEMBL4285351 | — | Ki | = | 1903.1 | nM | 5.72 |
| CHEMBL4284225 | — | Ki | = | 1956.6 | nM | 5.71 |
| CHEMBL4277762 | — | Ki | = | 1931.7 | nM | 5.71 |
| CHEMBL4291819 | — | Ki | = | 2231.8 | nM | 5.65 |
| CHEMBL4290322 | — | Ki | = | 2491.8 | nM | 5.60 |