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Assay Detail

CHEMBL4273196

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Antiproliferative activity against human MCF10A cells after 72 hrs by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type MCF-10A
Confidence 1 — Organism
Curated By Intermediate

Target

MCF-10A (CHEMBL614321)
Type CELL-LINE
Organism Homo sapiens

Publication

Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
Antoszczak M, Urbaniak A, Delgado M, Maj E, Borgström B, Wietrzyk J, Huczyński A, Yuan Y, Chambers TC, Strand D.
Eur J Med Chem (2018) 156 : 510 -523
PubMed 30025346 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.44 6.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 6.24
CHEMBL3236397 1 4.40
CHEMBL4289246 1 4.37
CHEMBL4294194 1 4.37
CHEMBL1208572 SALINOMYCIN 2.0 1 4.34
CHEMBL4283507 1 4.27
CHEMBL4278403 1 4.24
CHEMBL4278651 1 4.22
CHEMBL3236392 1 4.21
CHEMBL4291316 1 4.09
CHEMBL4290798 1 4.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 580.0 nM 6.24
CHEMBL3236397 IC50 = 40000.0 nM 4.40
CHEMBL4289246 IC50 = 43000.0 nM 4.37
CHEMBL4294194 IC50 = 43000.0 nM 4.37
CHEMBL1208572 SALINOMYCIN IC50 = 46000.0 nM 4.34
CHEMBL4283507 IC50 = 54000.0 nM 4.27
CHEMBL4278403 IC50 = 58000.0 nM 4.24
CHEMBL4278651 IC50 = 60000.0 nM 4.22
CHEMBL3236392 IC50 = 62000.0 nM 4.21
CHEMBL4291316 IC50 = 82000.0 nM 4.09
CHEMBL4290798 IC50 = 92000.0 nM 4.04