Assay Detail
Binding
CHEMBL4273246
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Inhibition of human 5-lipoxygenase using arachidonic acid as substrate pretreated for 10 mins followed by substrate and ATP addition and measured after 20 mins by H2DCFDA probe based fluorescence assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.99 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 7.00 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 6.82 |
| CHEMBL4280725 | — | — | 1 | 5.38 |
| CHEMBL4277548 | — | — | 1 | 5.01 |
| CHEMBL4284165 | — | — | 1 | 4.82 |
| CHEMBL4292477 | — | — | 1 | 4.54 |
| CHEMBL4287970 | — | — | 1 | 4.13 |
| CHEMBL4285912 | — | — | 1 | 4.11 |
| CHEMBL4291372 | — | — | 1 | 4.08 |
| CHEMBL4277332 | — | — | 1 | 4.02 |
| CHEMBL4295144 | — | — | 1 | - |
| CHEMBL4286799 | — | — | 1 | - |
| CHEMBL4283450 | — | — | 1 | - |
| CHEMBL4291296 | — | — | 1 | - |
| CHEMBL4285779 | — | — | 1 | - |
| CHEMBL4294783 | — | — | 1 | - |
| CHEMBL4287548 | — | — | 1 | - |
| CHEMBL4294609 | — | — | 1 | - |
| CHEMBL4282527 | — | — | 1 | - |
| CHEMBL4290401 | — | — | 1 | - |
| CHEMBL4293801 | — | — | 1 | - |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | - |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | - |
| CHEMBL4283079 | — | — | 1 | - |
| CHEMBL86304 | MOCLOBEMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL93 | ZILEUTON | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4280725 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4277548 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4284165 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL4292477 | — | IC50 | = | 28900.0 | nM | 4.54 |
| CHEMBL4287970 | — | IC50 | = | 74300.0 | nM | 4.13 |
| CHEMBL4285912 | — | IC50 | = | 77600.0 | nM | 4.11 |
| CHEMBL4291372 | — | IC50 | = | 82400.0 | nM | 4.08 |
| CHEMBL4277332 | — | IC50 | = | 95100.0 | nM | 4.02 |
| CHEMBL4295144 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4286799 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4283450 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4291296 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4285779 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4294783 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4287548 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4294609 | — | IC50 | - | — | - | |
| CHEMBL4282527 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4290401 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4293801 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL972 | SELEGILINE | IC50 | - | — | - | |
| CHEMBL92401 | IPRONIAZID | IC50 | - | — | - | |
| CHEMBL4283079 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | - | — | - |