Assay Detail
Binding
CHEMBL4273249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using p-tyramine as substrate pretreated for 15 mins followed by substrate addition by horse-radish peroxidase/amplex red-based fluorescence method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.57 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4287970 | — | — | 1 | 5.28 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.12 |
| CHEMBL4285912 | — | — | 1 | 4.87 |
| CHEMBL4280725 | — | — | 1 | 4.42 |
| CHEMBL4291296 | — | — | 1 | 4.29 |
| CHEMBL4282527 | — | — | 1 | 4.25 |
| CHEMBL4294609 | — | — | 1 | 4.22 |
| CHEMBL4290401 | — | — | 1 | 4.14 |
| CHEMBL4295144 | — | — | 1 | - |
| CHEMBL4286799 | — | — | 1 | - |
| CHEMBL4283450 | — | — | 1 | - |
| CHEMBL4285779 | — | — | 1 | - |
| CHEMBL4277548 | — | — | 1 | - |
| CHEMBL4292477 | — | — | 1 | - |
| CHEMBL4277332 | — | — | 1 | - |
| CHEMBL4291372 | — | — | 1 | - |
| CHEMBL4283079 | — | — | 1 | - |
| CHEMBL4294783 | — | — | 1 | - |
| CHEMBL4287548 | — | — | 1 | - |
| CHEMBL4293801 | — | — | 1 | - |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | - |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | - |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | - |
| CHEMBL86304 | MOCLOBEMIDE | 4.0 | 1 | - |
| CHEMBL4284165 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4287970 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4285912 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL4280725 | — | IC50 | = | 37900.0 | nM | 4.42 |
| CHEMBL4291296 | — | IC50 | = | 51200.0 | nM | 4.29 |
| CHEMBL4282527 | — | IC50 | = | 56400.0 | nM | 4.25 |
| CHEMBL4294609 | — | IC50 | = | 59900.0 | nM | 4.22 |
| CHEMBL4290401 | — | IC50 | = | 71600.0 | nM | 4.14 |
| CHEMBL4295144 | — | IC50 | - | — | - | |
| CHEMBL4286799 | — | IC50 | - | — | - | |
| CHEMBL4283450 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4285779 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4277548 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4292477 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4277332 | — | IC50 | - | — | - | |
| CHEMBL4291372 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4283079 | — | IC50 | - | — | - | |
| CHEMBL4294783 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4287548 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4293801 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL93 | ZILEUTON | IC50 | - | — | - | |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | - | — | - | |
| CHEMBL972 | SELEGILINE | IC50 | = | 17.0 | nM | - |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4284165 | — | IC50 | > | 100000.0 | nM | - |