Assay Detail
Functional
CHEMBL4273330
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Antileishmanial activity against Leishmania major promastigotes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania major |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New aziridine-based inhibitors of cathepsin L-like cysteine proteases with selectivity for the Leishmania cysteine protease LmCPB2.8.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.46 | 5.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4287060 | — | — | 1 | 5.01 |
| CHEMBL4294972 | — | — | 1 | 4.46 |
| CHEMBL382388 | — | — | 1 | 4.45 |
| CHEMBL4279254 | — | — | 1 | 4.43 |
| CHEMBL380076 | — | — | 1 | 4.40 |
| CHEMBL4289948 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4287060 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4294972 | — | EC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL382388 | — | EC50 | = | 35400.0 | nM | 4.45 |
| CHEMBL4279254 | — | EC50 | = | 37400.0 | nM | 4.43 |
| CHEMBL380076 | — | EC50 | = | 39600.0 | nM | 4.40 |
| CHEMBL4289948 | — | EC50 | = | 95000.0 | nM | 4.02 |