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Assay Detail

CHEMBL4273758

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Functional
Antiproliferative activity against human PANC1 cells after 48 hrs by propidium iodide staining-based fluorometric analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PANC-1
Confidence 1 — Organism
Curated By Intermediate

Target

PANC-1 (CHEMBL614139)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis, anticancer activity and molecular modeling studies of 1,2,4-triazole derivatives as EGFR inhibitors.
El-Sherief HAM, Youssif BGM, Abbas Bukhari SN, Abdelazeem AH, Abdel-Aziz M, Abdel-Rahman HM.
Eur J Med Chem (2018) 156 : 774 -789
PubMed 30055463 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.27 5.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4279008 1 5.55
CHEMBL4280192 1 5.46
CHEMBL4289274 1 5.46
CHEMBL4284701 1 5.35
CHEMBL4290355 1 5.35
CHEMBL4286943 1 5.31
CHEMBL4294910 1 5.28
CHEMBL4282482 1 5.28
CHEMBL4283643 1 5.18
CHEMBL4286998 1 5.14
CHEMBL4288100 1 5.13
CHEMBL4291511 1 5.06
CHEMBL4276757 1 5.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4279008 IC50 = 2800.0 nM 5.55
CHEMBL4280192 IC50 = 3500.0 nM 5.46
CHEMBL4289274 IC50 = 3500.0 nM 5.46
CHEMBL4284701 IC50 = 4500.0 nM 5.35
CHEMBL4290355 IC50 = 4500.0 nM 5.35
CHEMBL4286943 IC50 = 4900.0 nM 5.31
CHEMBL4294910 IC50 = 5200.0 nM 5.28
CHEMBL4282482 IC50 = 5200.0 nM 5.28
CHEMBL4283643 IC50 = 6600.0 nM 5.18
CHEMBL4286998 IC50 = 7200.0 nM 5.14
CHEMBL4288100 IC50 = 7400.0 nM 5.13
CHEMBL4291511 IC50 = 8700.0 nM 5.06
CHEMBL4276757 IC50 = 9500.0 nM 5.02