Assay Detail
Functional
CHEMBL4274071
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against wild type promastigote stage of Leishmania donovani MHOM/SD/62/1S-CL2D LdBOB after 72 hrs by resazurin dye based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.80 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4290387 | — | — | 1 | 5.85 |
| CHEMBL4277324 | — | — | 1 | 5.82 |
| CHEMBL2441910 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4290387 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4277324 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2441910 | — | IC50 | = | 1900.0 | nM | 5.72 |