Assay Detail
ADMET
CHEMBL4274073
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Substrate activity at recombinant nitroreductase 2 in promastigote stage of Leishmania donovani MHOM/SD/62/1S-CL2D LdBOB assessed as inhibition of parasite growth after 72 hrs by resazurin dye based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Leishmania donovani |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.65 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4290387 | — | — | 1 | 5.72 |
| CHEMBL4277324 | — | — | 1 | 5.70 |
| CHEMBL2441910 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4290387 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4277324 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2441910 | — | IC50 | = | 3000.0 | nM | 5.52 |