Assay Detail
ADMET
CHEMBL4274075
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Substrate activity at recombinant type-1 nitroreductase in bloodstream form of Trypanosoma brucei brucei S427 assessed as inhibition of parasite growth after 72 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Trypanosoma brucei brucei |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.78 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4288624 | — | — | 1 | 7.40 |
| CHEMBL4280330 | — | — | 1 | 6.72 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4288624 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4280330 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 600.0 | nM | 6.22 |