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Assay Detail

CHEMBL4274109

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H460
Confidence 1 — Organism
Curated By Intermediate

Target

NCI-H460 (CHEMBL396)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and pharmacological evaluation of new 3-(1H-benzimidazol-2-yl)quinolin-2(1H)-one derivatives as potential antitumor agents.
Kuang WB, Huang RZ, Qin JL, Lu X, Qin QP, Zou BQ, Chen ZF, Liang H, Zhang Y.
Eur J Med Chem (2018) 157 : 139 -150
PubMed 30092368 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 4.59 4.83

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4277308 1 4.83
CHEMBL4281821 1 4.78
CHEMBL4285263 1 4.62
CHEMBL4277339 1 4.62
CHEMBL4285686 1 4.52
CHEMBL4284272 1 4.44
CHEMBL185 FLUOROURACIL 4.0 1 4.34
CHEMBL4287659 1 -
CHEMBL4291507 1 -
CHEMBL4280866 1 -
CHEMBL4288098 1 -
CHEMBL4277454 1 -
CHEMBL4293404 1 -
CHEMBL4282792 1 -
CHEMBL4281856 1 -
CHEMBL4294907 1 -
CHEMBL4285293 1 -
CHEMBL118440 1 -
CHEMBL4293531 1 -
CHEMBL4292452 1 -
CHEMBL4278394 1 -
CHEMBL4289070 1 -
CHEMBL4276908 1 -
CHEMBL4280699 1 -
CHEMBL4292483 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4277308 IC50 = 14720.0 nM 4.83
CHEMBL4281821 IC50 = 16790.0 nM 4.78
CHEMBL4285263 IC50 = 24180.0 nM 4.62
CHEMBL4277339 IC50 = 23750.0 nM 4.62
CHEMBL4285686 IC50 = 30360.0 nM 4.52
CHEMBL4284272 IC50 = 36530.0 nM 4.44
CHEMBL185 FLUOROURACIL IC50 = 45440.0 nM 4.34
CHEMBL4287659 IC50 > 100000.0 nM -
CHEMBL4291507 IC50 > 100000.0 nM -
CHEMBL4280866 IC50 > 100000.0 nM -
CHEMBL4288098 IC50 > 100000.0 nM -
CHEMBL4277454 IC50 > 100000.0 nM -
CHEMBL4293404 IC50 > 100000.0 nM -
CHEMBL4282792 IC50 > 100000.0 nM -
CHEMBL4281856 IC50 > 100000.0 nM -
CHEMBL4294907 IC50 > 100000.0 nM -
CHEMBL4285293 IC50 > 100000.0 nM -
CHEMBL118440 IC50 > 100000.0 nM -
CHEMBL4293531 IC50 > 100000.0 nM -
CHEMBL4292452 IC50 > 100000.0 nM -
CHEMBL4278394 IC50 > 100000.0 nM -
CHEMBL4289070 IC50 > 100000.0 nM -
CHEMBL4276908 IC50 > 100000.0 nM -
CHEMBL4280699 IC50 > 100000.0 nM -
CHEMBL4292483 IC50 > 100000.0 nM -