Assay Detail
Functional
CHEMBL4274198
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Cytotoxicity against human MCF7 cells after 24 hrs by SRB assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, antiproliferative activity, molecular docking and cell cycle analysis of some novel (morpholinosulfonyl) isatins with potential EGFR inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.55 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.34 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 5.30 |
| CHEMBL4280749 | — | — | 1 | 4.96 |
| CHEMBL4284841 | — | — | 1 | 4.92 |
| CHEMBL4289728 | — | — | 1 | 4.68 |
| CHEMBL4289297 | — | — | 1 | 4.60 |
| CHEMBL4285307 | — | — | 1 | 4.57 |
| CHEMBL4282506 | — | — | 1 | 4.56 |
| CHEMBL4281426 | — | — | 1 | 4.52 |
| CHEMBL4277353 | — | — | 1 | 4.50 |
| CHEMBL4289083 | — | — | 1 | 4.48 |
| CHEMBL4277968 | — | — | 1 | 4.42 |
| CHEMBL4287569 | — | — | 1 | 4.41 |
| CHEMBL4278412 | — | — | 1 | 4.39 |
| CHEMBL4276927 | — | — | 1 | 4.39 |
| CHEMBL4292064 | — | — | 1 | 4.35 |
| CHEMBL4280602 | — | — | 1 | 4.35 |
| CHEMBL4292712 | — | — | 1 | 4.33 |
| CHEMBL4288648 | — | — | 1 | 4.28 |
| CHEMBL4285893 | — | — | 1 | 4.25 |
| CHEMBL4284186 | — | — | 1 | 4.25 |
| CHEMBL484273 | — | — | 1 | 4.17 |
| CHEMBL4293110 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL554 | LAPATINIB | IC50 | = | 5020.0 | nM | 5.30 |
| CHEMBL4280749 | — | IC50 | = | 10940.0 | nM | 4.96 |
| CHEMBL4284841 | — | IC50 | = | 11890.0 | nM | 4.92 |
| CHEMBL4289728 | — | IC50 | = | 20750.0 | nM | 4.68 |
| CHEMBL4289297 | — | IC50 | = | 25310.0 | nM | 4.60 |
| CHEMBL4285307 | — | IC50 | = | 26730.0 | nM | 4.57 |
| CHEMBL4282506 | — | IC50 | = | 27690.0 | nM | 4.56 |
| CHEMBL4281426 | — | IC50 | = | 30280.0 | nM | 4.52 |
| CHEMBL4277353 | — | IC50 | = | 31420.0 | nM | 4.50 |
| CHEMBL4289083 | — | IC50 | = | 33360.0 | nM | 4.48 |
| CHEMBL4277968 | — | IC50 | = | 38410.0 | nM | 4.42 |
| CHEMBL4287569 | — | IC50 | = | 39180.0 | nM | 4.41 |
| CHEMBL4278412 | — | IC50 | = | 40760.0 | nM | 4.39 |
| CHEMBL4276927 | — | IC50 | = | 41070.0 | nM | 4.39 |
| CHEMBL4292064 | — | IC50 | = | 44820.0 | nM | 4.35 |
| CHEMBL4280602 | — | IC50 | = | 44300.0 | nM | 4.35 |
| CHEMBL4292712 | — | IC50 | = | 46810.0 | nM | 4.33 |
| CHEMBL4288648 | — | IC50 | = | 52710.0 | nM | 4.28 |
| CHEMBL4285893 | — | IC50 | = | 56020.0 | nM | 4.25 |
| CHEMBL4284186 | — | IC50 | = | 55900.0 | nM | 4.25 |
| CHEMBL484273 | — | IC50 | = | 67940.0 | nM | 4.17 |
| CHEMBL4293110 | — | IC50 | = | 414000.0 | nM | - |