Assay Detail
Binding
CHEMBL4274256
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Inhibition of electric eel AChE using acetylthiocholine chloride as substrate incubated for 5 mins followed by substrate addition measured after 180 secs by Ellman's method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.08 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.30 |
| CHEMBL4292766 | — | — | 1 | 7.12 |
| CHEMBL4284475 | — | — | 1 | 6.50 |
| CHEMBL4281066 | — | — | 1 | 6.38 |
| CHEMBL4283390 | — | — | 1 | 6.28 |
| CHEMBL3819548 | — | — | 1 | 6.26 |
| CHEMBL4291697 | — | — | 1 | 6.25 |
| CHEMBL4293155 | — | — | 1 | 6.23 |
| CHEMBL4295126 | — | — | 1 | 6.17 |
| CHEMBL4284895 | — | — | 1 | 6.14 |
| CHEMBL4282558 | — | — | 1 | 6.13 |
| CHEMBL4278260 | — | — | 1 | 6.11 |
| CHEMBL3819320 | — | — | 1 | 6.09 |
| CHEMBL4288282 | — | — | 1 | 6.07 |
| CHEMBL4277644 | — | — | 1 | 6.06 |
| CHEMBL4292349 | — | — | 1 | 5.92 |
| CHEMBL4281727 | — | — | 1 | 5.88 |
| CHEMBL4287826 | — | — | 1 | 5.64 |
| CHEMBL4279488 | — | — | 1 | 5.61 |
| CHEMBL4286736 | — | — | 1 | 5.19 |
| CHEMBL4278298 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4292766 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4284475 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4281066 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4283390 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3819548 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4291697 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4293155 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4295126 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4284895 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4282558 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4278260 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL3819320 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4288282 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4277644 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4292349 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4281727 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4287826 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL4279488 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL4286736 | — | IC50 | = | 6430.0 | nM | 5.19 |
| CHEMBL4278298 | — | IC50 | = | 55610.0 | nM | 4.25 |