Assay Detail
ADMET
CHEMBL4274707
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against HMVEC-d cells after 4 days by Coulter counter method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of a 3'-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.72 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4287532 | — | — | 1 | 8.72 |
| CHEMBL4284518 | — | — | 1 | - |
| CHEMBL4295176 | — | — | 1 | - |
| CHEMBL4276891 | — | — | 1 | - |
| CHEMBL4277322 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4287532 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4284518 | — | IC50 | - | — | - | |
| CHEMBL4295176 | — | IC50 | < | 1.28 | nM | - |
| CHEMBL4276891 | — | IC50 | < | 1.28 | nM | - |
| CHEMBL4277322 | — | IC50 | < | 1.28 | nM | - |