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Assay Detail

CHEMBL4274996

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileukemic activity against human AML01 cells assessed as reduction in cell viability after 24 hrs by Annexin V/7-AAD staining based flow cytometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

MMB triazole analogs are potent NF-κB inhibitors and anti-cancer agents against both hematological and solid tumor cells.
Janganati V, Ponder J, Balasubramaniam M, Bhat-Nakshatri P, Bar EE, Nakshatri H, Jordan CT, Crooks PA.
Eur J Med Chem (2018) 157 : 562 -581
PubMed 30121494 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 5.55 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4284479 1 6.40
CHEMBL4290234 1 6.00
CHEMBL4280635 1 5.96
CHEMBL4288975 1 5.89
CHEMBL4278178 1 5.70
CHEMBL4292769 1 5.55
CHEMBL4291120 1 5.54
CHEMBL4281536 1 5.24
CHEMBL4298697 1 5.16
CHEMBL3582134 1 4.96
CHEMBL563939 1 4.62

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4284479 EC50 = 400.0 nM 6.40
CHEMBL4290234 EC50 = 1000.0 nM 6.00
CHEMBL4280635 EC50 = 1100.0 nM 5.96
CHEMBL4288975 EC50 = 1300.0 nM 5.89
CHEMBL4278178 EC50 = 2000.0 nM 5.70
CHEMBL4292769 EC50 = 2800.0 nM 5.55
CHEMBL4291120 EC50 = 2900.0 nM 5.54
CHEMBL4281536 EC50 = 5800.0 nM 5.24
CHEMBL4298697 EC50 = 7000.0 nM 5.16
CHEMBL3582134 EC50 = 11000.0 nM 4.96
CHEMBL563939 EC50 = 24000.0 nM 4.62