Assay Detail
Functional
CHEMBL4275082
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Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
63
Total Activities
63
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, biological evaluation and structure-activity relationship of sophoridine derivatives bearing pyrrole or indole scaffold as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 63 | 5.04 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4288799 | — | — | 1 | 5.71 |
| CHEMBL4286070 | — | — | 1 | 5.51 |
| CHEMBL4293682 | — | — | 1 | 5.51 |
| CHEMBL4278134 | — | — | 1 | 5.40 |
| CHEMBL4283411 | — | — | 1 | 5.40 |
| CHEMBL4289494 | — | — | 1 | 5.38 |
| CHEMBL4277059 | — | — | 1 | 5.38 |
| CHEMBL4283798 | — | — | 1 | 5.34 |
| CHEMBL4279235 | — | — | 1 | 5.34 |
| CHEMBL4283089 | — | — | 1 | 5.32 |
| CHEMBL4285009 | — | — | 1 | 5.27 |
| CHEMBL4295097 | — | — | 1 | 5.24 |
| CHEMBL4280486 | — | — | 1 | 5.23 |
| CHEMBL4282690 | — | — | 1 | 5.23 |
| CHEMBL4287171 | — | — | 1 | 5.22 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 5.22 |
| CHEMBL4288379 | — | — | 1 | 5.22 |
| CHEMBL4293990 | — | — | 1 | 5.21 |
| CHEMBL4286758 | — | — | 1 | 5.20 |
| CHEMBL4280340 | — | — | 1 | 5.18 |
| CHEMBL4277274 | — | — | 1 | 5.16 |
| CHEMBL4287146 | — | — | 1 | 5.16 |
| CHEMBL4292413 | — | — | 1 | 5.14 |
| CHEMBL4292210 | — | — | 1 | 5.14 |
| CHEMBL4287554 | — | — | 1 | 5.11 |
| CHEMBL4290573 | — | — | 1 | 5.09 |
| CHEMBL4282696 | — | — | 1 | 5.08 |
| CHEMBL4279229 | — | — | 1 | 5.08 |
| CHEMBL4287558 | — | — | 1 | 5.06 |
| CHEMBL4287831 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4288799 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4286070 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL4293682 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL4278134 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL4283411 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL4289494 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL4277059 | — | IC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL4283798 | — | IC50 | = | 4570.0 | nM | 5.34 |
| CHEMBL4279235 | — | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL4283089 | — | IC50 | = | 4830.0 | nM | 5.32 |
| CHEMBL4285009 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL4295097 | — | IC50 | = | 5720.0 | nM | 5.24 |
| CHEMBL4280486 | — | IC50 | = | 5860.0 | nM | 5.23 |
| CHEMBL4282690 | — | IC50 | = | 5940.0 | nM | 5.23 |
| CHEMBL4288379 | — | IC50 | = | 6070.0 | nM | 5.22 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 6080.0 | nM | 5.22 |
| CHEMBL4287171 | — | IC50 | = | 6010.0 | nM | 5.22 |
| CHEMBL4293990 | — | IC50 | = | 6170.0 | nM | 5.21 |
| CHEMBL4286758 | — | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL4280340 | — | IC50 | = | 6590.0 | nM | 5.18 |
| CHEMBL4277274 | — | IC50 | = | 6950.0 | nM | 5.16 |
| CHEMBL4287146 | — | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL4292413 | — | IC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL4292210 | — | IC50 | = | 7250.0 | nM | 5.14 |
| CHEMBL4287554 | — | IC50 | = | 7710.0 | nM | 5.11 |
| CHEMBL4290573 | — | IC50 | = | 8140.0 | nM | 5.09 |
| CHEMBL4279229 | — | IC50 | = | 8230.0 | nM | 5.08 |
| CHEMBL4282696 | — | IC50 | = | 8270.0 | nM | 5.08 |
| CHEMBL4287558 | — | IC50 | = | 8620.0 | nM | 5.06 |
| CHEMBL4287831 | — | IC50 | = | 8730.0 | nM | 5.06 |
| CHEMBL4294373 | — | IC50 | = | 9050.0 | nM | 5.04 |
| CHEMBL4287151 | — | IC50 | = | 9390.0 | nM | 5.03 |
| CHEMBL4290982 | — | IC50 | = | 9780.0 | nM | 5.01 |
| CHEMBL4289011 | — | IC50 | = | 9660.0 | nM | 5.01 |
| CHEMBL4207164 | — | IC50 | = | 9960.0 | nM | 5.00 |
| CHEMBL4278840 | — | IC50 | = | 10080.0 | nM | 5.00 |
| CHEMBL4281178 | — | IC50 | = | 10870.0 | nM | 4.96 |
| CHEMBL4282206 | — | IC50 | = | 12570.0 | nM | 4.90 |
| CHEMBL4278819 | — | IC50 | = | 12780.0 | nM | 4.89 |
| CHEMBL4292808 | — | IC50 | = | 13480.0 | nM | 4.87 |
| CHEMBL4282718 | — | IC50 | = | 13530.0 | nM | 4.87 |
| CHEMBL4288659 | — | IC50 | = | 13550.0 | nM | 4.87 |
| CHEMBL4276913 | — | IC50 | = | 14290.0 | nM | 4.84 |
| CHEMBL4291008 | — | IC50 | = | 14780.0 | nM | 4.83 |
| CHEMBL4281587 | — | IC50 | = | 15240.0 | nM | 4.82 |
| CHEMBL4276917 | — | IC50 | = | 15430.0 | nM | 4.81 |
| CHEMBL4284522 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL4290576 | — | IC50 | = | 16320.0 | nM | 4.79 |
| CHEMBL4290594 | — | IC50 | = | 16590.0 | nM | 4.78 |
| CHEMBL4277686 | — | IC50 | = | 17230.0 | nM | 4.76 |