Assay Detail
Functional
CHEMBL4275136
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Cytotoxicity against human EJ28 cells after 72 hrs by MTT assay
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Asymmetrical meta-methoxylated diarylpentanoids: Rational design, synthesis and anti-cancer evaluation in-vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 5.13 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4281949 | — | — | 1 | 5.77 |
| CHEMBL4280062 | — | — | 1 | 5.75 |
| CHEMBL4165781 | — | — | 1 | 5.62 |
| CHEMBL4293195 | — | — | 1 | 5.52 |
| CHEMBL4281516 | — | — | 1 | 5.47 |
| CHEMBL472887 | — | — | 1 | 5.46 |
| CHEMBL4283976 | — | — | 1 | 5.44 |
| CHEMBL4288721 | — | — | 1 | 5.38 |
| CHEMBL4283526 | — | — | 1 | 5.38 |
| CHEMBL3754599 | — | — | 1 | 5.34 |
| CHEMBL4294779 | — | — | 1 | 5.31 |
| CHEMBL4294158 | — | — | 1 | 5.27 |
| CHEMBL4279628 | — | — | 1 | 5.24 |
| CHEMBL4290754 | — | — | 1 | 5.19 |
| CHEMBL4170254 | — | — | 1 | 5.18 |
| CHEMBL4286266 | — | — | 1 | 5.16 |
| CHEMBL4286881 | — | — | 1 | 5.15 |
| CHEMBL4290287 | — | — | 1 | 5.13 |
| CHEMBL4286089 | — | — | 1 | 5.12 |
| CHEMBL4289820 | — | — | 1 | 5.10 |
| CHEMBL4291366 | — | — | 1 | 5.09 |
| CHEMBL477057 | — | — | 1 | 5.08 |
| CHEMBL4287965 | — | — | 1 | 5.08 |
| CHEMBL4277375 | — | — | 1 | 5.07 |
| CHEMBL4292516 | — | — | 1 | 5.00 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.98 |
| CHEMBL4295235 | — | — | 1 | 4.98 |
| CHEMBL4291126 | — | — | 1 | 4.97 |
| CHEMBL3751960 | — | — | 1 | 4.97 |
| CHEMBL4278976 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4281949 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4280062 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4165781 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4293195 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4281516 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL472887 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4283976 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4288721 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4283526 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3754599 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4294779 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4294158 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4279628 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4290754 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4170254 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4286266 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4286881 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4290287 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4286089 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4289820 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4291366 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL477057 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4287965 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4277375 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4292516 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL140 | CURCUMIN | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4295235 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4291126 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3751960 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4278976 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4289653 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4282433 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4295182 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL3794522 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL4160745 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL4292141 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4171844 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL4166258 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL4281230 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL4284585 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL4280779 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL4287337 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL4278062 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4289185 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4291424 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4280535 | — | IC50 | > | 20000.0 | nM | - |