Assay Detail
Functional
CHEMBL4275367
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Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and SAR of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as potent and selective CDK4/6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.80 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4286430 | — | — | 1 | 6.72 |
| CHEMBL4289852 | — | — | 1 | 6.66 |
| CHEMBL4278514 | — | — | 1 | 6.46 |
| CHEMBL4290012 | — | — | 1 | 6.15 |
| CHEMBL4288758 | — | — | 1 | 6.11 |
| CHEMBL556881 | — | — | 1 | 6.03 |
| CHEMBL560817 | — | — | 1 | 5.98 |
| CHEMBL4281978 | — | — | 1 | 5.74 |
| CHEMBL4281557 | — | — | 1 | 5.67 |
| CHEMBL562104 | — | — | 1 | 5.51 |
| CHEMBL4287981 | — | — | 1 | 5.43 |
| CHEMBL4294376 | — | — | 1 | 5.37 |
| CHEMBL4279646 | — | — | 1 | 5.32 |
| CHEMBL559845 | — | — | 1 | 5.24 |
| CHEMBL4283123 | — | — | 1 | 5.22 |
| CHEMBL4293299 | — | — | 1 | 5.17 |
| CHEMBL4277343 | — | — | 1 | - |
| CHEMBL4292180 | — | — | 1 | - |
| CHEMBL4287560 | — | — | 1 | - |
| CHEMBL4294798 | — | — | 1 | - |
| CHEMBL4293228 | — | — | 1 | - |
| CHEMBL560818 | — | — | 1 | - |
| CHEMBL1098059 | — | — | 1 | - |
| CHEMBL4286071 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4286430 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4289852 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4278514 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4290012 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4288758 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL556881 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL560817 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4281978 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL4281557 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL562104 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4287981 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL4294376 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4279646 | — | IC50 | = | 4770.0 | nM | 5.32 |
| CHEMBL559845 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4283123 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4293299 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4277343 | — | IC50 | - | — | - | |
| CHEMBL4292180 | — | IC50 | - | — | - | |
| CHEMBL4287560 | — | IC50 | - | — | - | |
| CHEMBL4294798 | — | IC50 | - | — | - | |
| CHEMBL4293228 | — | IC50 | - | — | - | |
| CHEMBL560818 | — | IC50 | - | — | - | |
| CHEMBL1098059 | — | IC50 | - | — | - | |
| CHEMBL4286071 | — | IC50 | - | — | - |