Assay Detail
Functional
CHEMBL4275384
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Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and evaluation of cystargolide-based β-lactones as potent proteasome inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.09 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL451887 | CARFILZOMIB | 4.0 | 1 | 8.36 |
| CHEMBL4290778 | — | — | 1 | 7.13 |
| CHEMBL4292698 | — | — | 1 | 6.66 |
| CHEMBL4285979 | — | — | 1 | 6.56 |
| CHEMBL4276815 | — | — | 1 | 6.55 |
| CHEMBL4293877 | — | — | 1 | 6.54 |
| CHEMBL4292745 | — | — | 1 | 6.51 |
| CHEMBL4278729 | — | — | 1 | 6.51 |
| CHEMBL4282198 | — | — | 1 | 6.50 |
| CHEMBL4287467 | — | — | 1 | 6.47 |
| CHEMBL4282642 | — | — | 1 | 6.17 |
| CHEMBL4293806 | — | — | 1 | 6.17 |
| CHEMBL4278670 | — | — | 1 | 6.16 |
| CHEMBL4292798 | — | — | 1 | 6.05 |
| CHEMBL4293394 | — | — | 1 | 5.84 |
| CHEMBL4283227 | — | — | 1 | 5.72 |
| CHEMBL4282576 | — | — | 1 | 5.54 |
| CHEMBL4289394 | — | — | 1 | 5.49 |
| CHEMBL4282369 | — | — | 1 | 5.47 |
| CHEMBL4281941 | — | — | 1 | 5.42 |
| CHEMBL4280626 | — | — | 1 | 5.28 |
| CHEMBL4280675 | — | — | 1 | 4.55 |
| CHEMBL4294463 | — | — | 1 | 4.52 |
| CHEMBL4288920 | — | — | 1 | - |
| CHEMBL4286462 | — | — | 1 | - |
| CHEMBL4282765 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL451887 | CARFILZOMIB | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4290778 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4292698 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL4285979 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL4276815 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4293877 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL4292745 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL4278729 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL4282198 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL4287467 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL4282642 | — | IC50 | = | 678.0 | nM | 6.17 |
| CHEMBL4293806 | — | IC50 | = | 673.0 | nM | 6.17 |
| CHEMBL4278670 | — | IC50 | = | 699.0 | nM | 6.16 |
| CHEMBL4292798 | — | IC50 | = | 885.0 | nM | 6.05 |
| CHEMBL4293394 | — | IC50 | = | 1453.0 | nM | 5.84 |
| CHEMBL4283227 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL4282576 | — | IC50 | = | 2859.0 | nM | 5.54 |
| CHEMBL4289394 | — | IC50 | = | 3217.0 | nM | 5.49 |
| CHEMBL4282369 | — | IC50 | = | 3349.0 | nM | 5.47 |
| CHEMBL4281941 | — | IC50 | = | 3756.0 | nM | 5.42 |
| CHEMBL4280626 | — | IC50 | = | 5211.0 | nM | 5.28 |
| CHEMBL4280675 | — | IC50 | = | 28170.0 | nM | 4.55 |
| CHEMBL4294463 | — | IC50 | = | 30320.0 | nM | 4.52 |
| CHEMBL4288920 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4286462 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4282765 | — | IC50 | - | — | - |