Assay Detail
Functional
CHEMBL4275385
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Cytotoxicity against human RPMI8226 cells after 48 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and evaluation of cystargolide-based β-lactones as potent proteasome inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.18 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL451887 | CARFILZOMIB | 4.0 | 1 | 8.17 |
| CHEMBL4290778 | — | — | 1 | 7.39 |
| CHEMBL4278729 | — | — | 1 | 7.07 |
| CHEMBL4285979 | — | — | 1 | 7.06 |
| CHEMBL4282198 | — | — | 1 | 7.02 |
| CHEMBL4276815 | — | — | 1 | 6.94 |
| CHEMBL4293877 | — | — | 1 | 6.72 |
| CHEMBL4287467 | — | — | 1 | 6.57 |
| CHEMBL4292745 | — | — | 1 | 6.57 |
| CHEMBL4292698 | — | — | 1 | 6.54 |
| CHEMBL4289394 | — | — | 1 | 6.52 |
| CHEMBL4292798 | — | — | 1 | 6.50 |
| CHEMBL4278670 | — | — | 1 | 6.13 |
| CHEMBL4282642 | — | — | 1 | 6.12 |
| CHEMBL4282369 | — | — | 1 | 5.96 |
| CHEMBL4280626 | — | — | 1 | 5.93 |
| CHEMBL4293806 | — | — | 1 | 5.92 |
| CHEMBL4282576 | — | — | 1 | 5.77 |
| CHEMBL4283227 | — | — | 1 | 5.76 |
| CHEMBL4293394 | — | — | 1 | 5.65 |
| CHEMBL4280675 | — | — | 1 | 5.63 |
| CHEMBL4281941 | — | — | 1 | 5.58 |
| CHEMBL4294463 | — | — | 1 | 4.47 |
| CHEMBL4288920 | — | — | 1 | 4.43 |
| CHEMBL4286462 | — | — | 1 | 4.13 |
| CHEMBL4282765 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL451887 | CARFILZOMIB | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4290778 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4278729 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4285979 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4282198 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4276815 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL4293877 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL4287467 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL4292745 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL4292698 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL4289394 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL4292798 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4278670 | — | IC50 | = | 748.0 | nM | 6.13 |
| CHEMBL4282642 | — | IC50 | = | 762.0 | nM | 6.12 |
| CHEMBL4282369 | — | IC50 | = | 1103.0 | nM | 5.96 |
| CHEMBL4280626 | — | IC50 | = | 1176.0 | nM | 5.93 |
| CHEMBL4293806 | — | IC50 | = | 1217.0 | nM | 5.92 |
| CHEMBL4282576 | — | IC50 | = | 1706.0 | nM | 5.77 |
| CHEMBL4283227 | — | IC50 | = | 1748.0 | nM | 5.76 |
| CHEMBL4293394 | — | IC50 | = | 2243.0 | nM | 5.65 |
| CHEMBL4280675 | — | IC50 | = | 2346.0 | nM | 5.63 |
| CHEMBL4281941 | — | IC50 | = | 2608.0 | nM | 5.58 |
| CHEMBL4294463 | — | IC50 | = | 33520.0 | nM | 4.47 |
| CHEMBL4288920 | — | IC50 | = | 37220.0 | nM | 4.43 |
| CHEMBL4286462 | — | IC50 | = | 73860.0 | nM | 4.13 |
| CHEMBL4282765 | — | IC50 | - | — | - |