Assay Detail
ADMET
CHEMBL4275400
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Cytotoxicity against human MCF10A cells assessed as decrease in cell viability after 3 days by WST-1 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationship and pharmacokinetic studies of 3-O-substitutedflavonols as anti-prostate cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.79 | 5.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31574 | FISETIN | 2.0 | 1 | 5.61 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.92 |
| CHEMBL4286344 | — | — | 1 | 4.68 |
| CHEMBL77198 | — | — | 1 | 4.62 |
| CHEMBL4284158 | — | — | 1 | 4.47 |
| CHEMBL4286004 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31574 | FISETIN | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL50 | QUERCETIN | IC50 | = | 11970.0 | nM | 4.92 |
| CHEMBL4286344 | — | IC50 | = | 20930.0 | nM | 4.68 |
| CHEMBL77198 | — | IC50 | = | 23950.0 | nM | 4.62 |
| CHEMBL4284158 | — | IC50 | = | 33750.0 | nM | 4.47 |
| CHEMBL4286004 | — | IC50 | = | 35690.0 | nM | 4.45 |